Mike Clay and Joe Fortenbaugh offer their best bets.
Note: Odds courtesy of Caesars Sportsbook. Odds as of Sunday.
Cleveland Browns at San Francisco 49ers (-5, 47)
George Kittle over 63.5 receiving yards (-110)
Clay: Last season, Kittle went over this mark in 11 of 16 games and set an NFL tight end record with 1,377 receiving yards. That works out to 86.1 yards per game, which is obviously well above this line. Kittle hasn't been quite as productive out of the gate in 2019, of course, but is still averaging 55.0 yards per game. Kittle has handled at least eight targets in two of three games this season, and the exception was a Week 2 blowout win over Cincinnati in which he was limited by game script to 16 routes and four targets. A route isn't nearly as likely against Cleveland this week, so Kittle's 26% target share (which, by the way, is barely below his 27% share from 2018) should be enough to get him over 63 receiving yards.