Georgia Southern (14-9, 6-4 Sun Belt Conference) shot 54 percent from the floor, 35 of 65, and drained 10 of 15 shots from behind the 3-point arc.
Brown, with three, and Jackson, with four, combined for the bulk of the Eagles 3-pointers. The pair nailed consecutive treys to break an early tie, giving Georgia Southern a 13-6 lead. The lead grew as large as 17 points for a 51-38 advantage at the half.
The Eagles opened the second half on a 9-3 pace, including 3-pointers by Calvin Wishart and Brown, and were up by as many as 25.
The Eagles, who remain in a tight bunch with the top five teams in the Sun Belt, scored the most points in a conference game since 2005.
The Ragin' Cajuns (13-10, 4-6) have lost their third in a row, giving up 104, 96 and 103 points.
No. 9 Virginia desperate to find deep stroke vs. Columbia
No. 9 Virginia outscored its first two opponents by a combined 45 points despite shooting 16 percent from 3-point distance.
What James Wiseman's ineligibility means for Memphis
James Wiseman was ruled ineligible Thursday. His return to Memphis is uncertain. How talented are the Tigers without him?
Texas A&M suspends TJ Starks indefinitely for violation of team rules
Texas A&M has suspended TJ Starks indefinitely for violation of team rules.