The Monarchs have claimed victory in 12 of their last 14 games.
Xavier Green added 13 points and five assists for Old Dominion (14-5, 4-2 Conference USA). The Monarchs hit 10 of 26 from 3-point range, 10 of 20 at the free-throw line and outrebounded Southern Miss 45-32.
The Monarchs ended the first half on a 25-7 run for a 40-29 lead after connecting on 7 of 16 from distance.
It was Southern Miss's eighth road game in its last 10 contests.
Hassan Diarra commits to play for Aggies, coach Buzz Williams
Guard Hassan Diarra, who averaged 13.2 points, 4.6 rebounds and 4.1 assists on the Nike EYBL circuit last spring and summer, has committed to Texas A&M and coach Buzz Williams.
White says Nembhard is pretty unique
There are high expectations for guard Andrew Nembhard this season as he exhibits great leadership as a sophomore.
Gators have to get better in order to max out as a team
Florida head coach Mike White and guard Andrew Nembhard join the SEC Now desk to discuss Nembhard's growing leadership.