Santa Clara opened the game on a 16-2 run and, after Denver closed within 35-31 at the break, scored 45 points in the second half.
Keshawn Justice chipped in 16, and Josip Vrankic had 13 points, 10 rebounds and seven assists for Santa Clara (6-1), which earned its sixth straight home victory. Caruso also had seven rebounds and three blocks.
Santa Clara plays Southeast Missouri at home on Friday. Denver takes on Cal State Fullerton on Friday.
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Elements of this story was generated by Automated Insights, http://www.automatedinsights.com/ap, using data from STATS LLC, https://www.stats.com