The sophomore forward from Indianapolis has hired an agent and declared for the NBA draft.
Wilkes led the Bruins in scoring this season, averaging 17.4 points and 4.8 rebounds. He was named to the All-Pac-12 second team.
The Bruins finished 17-16 after coach Steve Alford was fired at the end of December and Murry Bartow served as interim for the rest of the season. UCLA didn't make the NCAA Tournament a year after losing to St. Bonaventure in a First Four game.
Wilkes announced his intentions via Twitter on Wednesday.
Wilkes declared for the NBA draft last season but didn't hire an agent to preserve his eligibility and later returned to school.
He is No. 73 on ESPN's rankings of the top 100 prospects.
The Associated Press contributed to this report.